Oral Presentation Australasian Diabetes in Pregnancy Society and Society of Obstetric Medicine Australia and New Zealand Joint Scientific Meeting 2021

Outcomes of pregnancies to women with cystic fibrosis in South East QLD (#17)

Sarah Davidson 1 2 , Megan France 3 , Peter Hopkins 3 , Dan Chambers 3 , Scott Bell 4 5 , Lucy Burr 6 7 , Rebecca Keating 6 7 , Leonie K Callaway 1 8 , Karin Lust 1 , Helen L Barrett 9 10
  1. Royal Brisbane and Women's Hospital , Herston, QLD, Australia
  2. School of Medicine, Duke University, Durham, NC 27705, USA
  3. Adult Cystic Fibrosis Centre, Thoracic Medicine, The Prince Charles Hospital, Brisbane, QLD, Australia
  4. Child Health Research Centre, The University of QLD, St Lucia, QLD, Australia
  5. Thoracic Medicine, The Prince Charles Hospital, Brisbane, QLD, Australia
  6. Mater Research Institute - The University of QLD, Brisbane
  7. Respiratory, Mater Health, South Brisbane, QLD, Australia
  8. Faculty of Medicine, University of Queensland, Herston, QLD, Australia
  9. Endocrinology, Mater Health, South Brisbane, QLD, Australia
  10. Mater Research Institute - The University of QLD, Brisbane, QLD, Australia

Background: Pregnancy in women with cystic fibrosis (CF) is becoming more common and the general health of people with CF is increasing. Longer term metabolic issues such as overweight and diabetes are also rising and have potential important impacts on pregnancy outcomes.

Aim: The intention of this study was to assess the impact of diabetes on pregnancy outcome for women with cystic fibrosis.

Methods: We have undertaken a multisite retrospective chart audit of pregnancies over a ten year period 2006-2016 to women with cystic fibrosis at the two quaternary obstetric hospitals in south east Queensland who are associated with cystic fibrosis management clinics.

Results: 38 pregnancies amongst 26 women were identified. Two women had previously had lung transplant. Seventeen pregnancies were primiparous, and one a twin pregnancy. Five women had cystic fibrosis related diabetes (CFRD) diagnosed prior to pregnancy. A further twelve women had fifteen pregnancies complicated by gestational diabetes (GDM). Average gestational age of delivery was 36 weeks. CFRD and GDM were associated with higher rates of preeclampsia (CFRD 60%/GDM 0/No diabetes 0), delivery complications, prematurity (80%/60%/44%), NICU admission (80%/47%/28%), neonatal hypoglycaemia and neonatal respiratory distress.

Conclusions: Diabetes is common during pregnancy in women with cystic fibrosis and appears to impact on pregnancy outcomes. Ideally collation of data in a national cohort would allow tracking and reporting of pregnancy outcomes for this cohort of women who have high risk of adverse pregnancy outcomes.